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way, a system could be identi ed as the set of practices that has strong performance effects. Since any reactive effect between the practices will occur regardless of whether they tend in general to coexist, it is an alternative concept to that underlying the latent variable analysis of Wood and his colleagues. Their notion, that integrated management is ultimately an underlying orientation, implies that the practices form a coherent system that re ects management s use of them as a package, albeit to varying degrees, and does not imply synergistic effects between practices but rather, as we have seen, that this coexistence will be explained by a common factor. Moreover, it may well be that although the practices form an integrated set, their collective use may not result in superior performance to other packages that re ect other integrated approaches. It is thus necessary to differentiation between synergistic and orientation-type arguments. We shall review the literature, rst presenting the research which has attempted to examine synergy, ordering this according to the extent to which it has found any, before concluding with the one study based on orientations.

that a user in Europe and a user in Australia could communicate with each other on a regular basis with a message delivery time of only two days. The uses for the above mail networks are limited only by one s imagination. These networks could be used to unite hackers all over the world at an almost negligible cost.

The health care revolution brought about by nanotechnology could dwarf all other trends in the history of medical technology. Nanomedicine will pose unique challenges to the FDA in terms of classification, regulatory approval, and maintaining scientific expertise. The agency must begin to prepare now for this coming revolution in medicine. First, the agency should contemplate what measures to take in preparation for nanomedicine. It should sponsor conferences and workshops focused on identifying and fleshing out the issues associated with nanomedicine. The fruit of these efforts should be the promulgation of Points to Consider documents that initiate a dialogue between the agency and the emerging nanomedical industry. Indeed, the agency appears to be moving in this direction. By the time this book goes to press, the FDA will have put nanotechnology in the spotlight at the 2004 Science Forum. Second, the FDA should consider establishing an Office of Nanotechnology. Like the former Office of Biotechnology, the Office would advise the commissioner and other FDA officials on nanotechnology science and policy, represent the FDA on nanotechnology matters to other agencies, industry, academia, and Congress, direct agency research and training, and attempt to recruit and retain scientists with needed expertise. Third, in addressing the categorization problems posed by nanotechnology, the FDA should attempt to identify in advance what Centers will have primary jurisdiction over such products. For example, the Office of Combination Products should draft clear guidelines for drug delivery products based on nanotechnology. Similarly, in addressing the problem of determining the requisite level of data needed to approve nanotechnology-enhanced products, FDA should consider promulgating guidances. For example, in the case of specific drug delivery mechanisms based on nanotechnology, the agency could clearly define how much additional clinical data are needed when a company submits

(Continued)

Figure 6-4

Legend 4 4 4 4 4 24 24 24 24 24 8 8 8 8 8 40 40 40 40 40 8 8 8 8 8 8 24 24 24 24 24 24 24 24 24 24 24 24 24 24 8 8 8 8 8 8

Although much of the need for MakeProcInstance has gone away with newer compilers, this function is usually required in cases where you want callback functions in your EXE's code rather than in a DLL For example, you might want to use TOOLHELP NotifyRegister or InterruptRegister callbacks in your EXE's code If you use the __loadds function modifier, you'll end up limiting the program to a single instance MakeProcInstance thunks come to the rescue in such situations The job of the MakeProclnstance thunk is simple: Jump to a specified address after setting the AX register to the DS register value that the function should use It's expected that the function's prologue code will take the AX register value and put it into DS MakeProclnstance has parameter validation layer code that first makes sure that a valid target address and HINSTANCE were passed.

2000). In these studies, the stressors are associated with challenge, and proactive and innovative behaviours become coping strategies. Therefore, it is likely that the effect of stressors on proactivity and innovation depends upon the appraisal of the stressor as either anxiety-provoking or an achievable challenge. Interestingly, Amabile et al., (1996) measured both excessive workload (italics added) and challenge: the rst hindered innovation, while the second helped. As this nding also suggests, the appraisal, and its subsequent effects, are dependent upon the degree to which the stressor exists. This is likely to be a U-shaped curve. Without necessity or stress there is little motivation to engage in the behaviours; too much stress may lead to anxiety, which may be detrimental, but a certain amount of challenge and necessity may be bene cial to proactivity and innovation.

The audit committee also considers the adequacy of the internal audit organization. Is it large enough Does it have the proper level of competence For example, do the auditors know how to audit the latest computer systems In many companies, the internal audit organization is a training ground where promising